🔥 Molibresib (I-BET) | エピジェネティックリーダードメイン 阻害剤

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GSK (iBET-BD2) is a selective and oral active inhibitor of BD2, with the IC50s of nM (BRD2 BD2), 98 nM (BRD3 BD2), GSK exhibits Cmax (mouse , rat ng/mL) and terminal elimination half-lives (mouse , rat h)

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Molibresib (I-BET, GSK, GSKA) is an inhibitor for BET proteins with IC50 of ~35 nM in a cell-free assay, suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation, highly​

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